The Ethicon DERMABOND PRINEO® Skin Closure System CLR422 is an advanced wound closure solution combining a topical 2-octyl cyanoacrylate adhesive with a flexible, self-adhering polyester mesh to support secure skin edge approximation following surgical procedures.

Designed for use on clean surgical incisions, the PRINEO® system distributes tension evenly across the wound while forming a flexible, water-resistant microbial barrier. The integrated mesh structure reinforces incision lines and supports improved cosmetic healing outcomes compared with traditional external closure methods such as staples.

Upon application, the adhesive polymerises rapidly to form a strong protective film that remains in place during early healing and naturally separates as the skin regenerates. The system is intended for professional surgical use following appropriate deep dermal closure where indicated.

Supplied sterile and single-use, CLR422 is part of the Ethicon wound closure portfolio and is designed for advanced adhesive mesh skin closure in clinical environments.

• Key Features
• • Combination adhesive and mesh wound closure system
• • 2-octyl cyanoacrylate topical adhesive
• • Self-adhering polyester mesh
• • Even tension distribution across incision
• • Flexible, protective microbial barrier
• • Alternative to staples or external sutures in suitable cases
• • Designed for surgical skin closure
• • Sterile, single-use
• Technical Specifications
• Brand: Ethicon
• Product Code: CLR422
• Product Name: DERMABOND PRINEO® Skin Closure System
• Material: 2-Octyl Cyanoacrylate + Polyester Mesh
• Absorbability: Non-absorbable (topical film system)
• Needle: Not applicable
• Strands Per Pack: Not applicable
• Pledget: No
• Category: Ethicon Wound Closure
• Suitable For
• • Closure of clean surgical incisions
• • Orthopaedic and general surgery skin closure
• • Minimally invasive procedure incisions
• • Cosmetic surgical applications
• • Situations requiring adhesive mesh reinforcement